No, there shouldn’t be any difference at all. Cleansers are only good for cleaning away dirt, oil, and makeup and that’s it! Any anti-wrinkle product needs to stay in contact with your skin for considerable period of time for it to have any kind of effect (you know, like a cream). If you were buying this cleanser for it’s anti-wrinkle claims I would tell you not to waste your money because you’ll be washing it all down the drain. But since you’re only after the anti-blemish properties, go ahead! It won’t affect you at all.