suffers from Parkinson's disease, then this is going to be one of the most important things you'll ever read.MDTV: Parkinson’s Disease Dementia
29.07.10 / parkinson disease / Author: Alex
Tags: dementia, Disease, MDTV, parkinsons
“Parkinson’s Disease Dementia” featuring Neurologist, Dr. Dee Silver, discusses how Parkinson’s patients are 4 to 6 times more likely to develop some cognitive impairment. Up to 1 million people in the US are affected by IPD. After patients have had the disease 8 to 10 years, they have about an 80% chance of developing cognitive impairment. Dr. Silver talks about a new drug (Excelon) that is shown to hold off these impairments. Series: “MDTV (Medical Doctor Television) ” [12/2007] [Health and Medicine] [Show ID: 13686]
Vision Shopsters: Biomarkers in Parkinsons Disease 2010
This report presents a comprehensive update on PD biomarker developments up to April 2010. It covers the major classes of emerging and new markers relating to PD (blood, CSF, metabolomic, image-based, genetic and others), and focuses on those investigated in controlled human studies. This includes single and combined markers.
Parkinson’s disease (PD) is the second most-common neurodegenerative disorder (after Alzheimer’s disease), and affects movement control. This condition develops due to the loss of dopamine-producing nerve cells in the Substantia Nigra, located in the mid brain. According to the US National Parkinson Foundation (NPF), 50 to 60,000 new cases of PD are diagnosed every year in the US, and one million people in the US already have the disease. Individual country incidence rates vary, but the NPF estimates that four to six million people around the world suffer from this condition.
In most cases, PD is diagnosed clinically. While this successfully identifies >90% of individuals requiring treatment for this condition, findings show that the first motor symptoms, such as bradykinesia, rigidity and tremor, may not occur until 30 to 50% of dopaminergic neurones have already been lost. This scenario creates an urgent need for tests that enable PD to be detected in its earliest stages, to allow appropriate treatment to begin.
Important advances have been made in the diagnosis of PD using imaging methods such as fluorodopa-PET and dopamine transporter SPECT. However, while these methods are important in clinical research, they are complex, expensive, not widely available and inappropriate for the routine screening of large populations. Likewise, genetic testing is important to PD in establishing traits, predisposition and risk but these tests do not or may not confirm the manifest presence of the disease.
These limitations create an urgent need for objective tests that detect and diagnose PD in its earliest stages, to allow appropriate treatments to begin. Such tests, if they are to meet patient requirements, should be simple, inexpensive, able to be used close to the clinical setting and available to all. Today, biomarkers are at the centre of efforts to develop these test capabilities.
This report presents a comprehensive update on PD biomarker developments up to April 2010. It covers the major classes of emerging and new markers relating to PD (blood, CSF, metabolomic, image-based, genetic and others), and focuses on those identified or investigated in controlled human studies. This includes single and combined markers.
This in-depth analysis of developments to date identified more than 45 PD biomarkers that are differentially expressed in PD, relative to controls. Of these, more than 40% are found in the blood or CSF. Combinations or multi-analyte profiles were considered as “single markers” for the purpose of this analysis. While efforts to identify markers to help understand or diagnose PD are at an early stage, important advances have been made in the last three years and show considerable promise. A number of companies and specialist groups (identified in this report) are working on the development of new marker-based diagnostic tests for PD. Recent advances in the identification of biomarkers in this field offer diagnostic opportunities and point the way to new therapeutic strategies.
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HOPE: Four Keys to a Better Quality of Life for Parkinson’s People
This book is a book of hope for both the newly diagnosed Parkinson’s Person as well as a helpful reminder to a better quality of life for those who have had the disease for many years. The writing is succinct and easy to read. Hal outlines the four basics of hope as 1) Help; 2) Optimism; 3) Physician; and 4) Exercise. His personal stories on these four points are candid and powerful. He has experienced some changes in his life as a result of Parkinson’s but he remains positive, upbeat and
Rating: 
(out of 11 reviews)
List Price: $ 12.00
Price: $ 10.99
Stanford study identifies molecular mechanism triggering Parkinson’s Disease
In a multi-step malfunction, a genetic mutation linked to Parkinson’s Disease causes impairment of molecules called microRNAs, ultimately causing death of critical brain cells.
Read more on Oakland Tribune
Question by Darby: Can you join the US Coast Guard if you have Wolff Parkinson White disease?
This is very important. If anyone at all has any helpful information I would greatly appreciate it! For anyone who doesn’t know, Wolff Parkinson White disease is a heart condition that causes your heart rate to increase when you do extensive physical activity. Thanks in advance for all your help.
Best answer:
Answer by Jennifer S
According to what I’ve been reading, anything that is not correctable via surgery will bar you from serving.
It lists Wolff Parkinson specifically.
What do you think? Answer below!
I Love You, Mom.
Image by rezlab
It’s tough getting older. Mom struggles with Parkinson’s disease, which generally makes it very tough to move around. However, as Mom says, she is "One Tough Bird" and I very rarely hear her complain.
Comments: 55
Great. Another Drug Commercial – Now on YouTube.
Thanks
Genetic cuases of Alzheimers tend to be primarily associated to the much rarer form of young age onset. However, for normal predominantly idiopathic Alzhiemers Apolipoprotien epsilon has been implicated in predisposing to it. As far as this gene is concerned it contains two single nucleotide polymorphisms, with 4 identified versions of the gene in humans. However as I’m not an expert in gene thrapy I wouldnt know how to go about altering it, other than just inserting a new copy of a benine form
In reguards to current medication unfortunately there isn’t much available, as essentially they treat the symptoms rather than the cuase, so deteriation will still occur. As far as antioxidants go lipoic acid seems like a pluasable option as can upregulate endogenous antioxidants (nrf2-keap1 system) and seems to act as an iron chelator. (also see curamin). However I wouldn’t expect an improvment of symptoms, rather retard the deteriation in brain function. hopefully that helped a little?
Would you endorse taking R-Lipoic Acid to combat central Fe. My father is getting into the later stages (about 7-10 years of known symptoms) and I can see that his memory is losing ground. Is there anything that can try to cut to the source of the deterioration instead of just squeezing more dopamine out of his brain with current meds. Thanks!
Hi mdrummond. Maybe, but is there any possibility of salvage due to genetic wobble ?
Amyloid plaques contain central Fe which produces superoxide via fenton reaction, which cause lipid peroxidation and subsequent damage to proteins and DNA. Amyloid also can bind to scavanger receptors enhanceing cdk5 activation, leading to apoptosis activation and tau phosphorylation i.e neurofirbillary tangles. Also via similar mechanisms they can cause inflammation leading to the release of cytokines NO etc. it can lead to glutamate hypersensitivity leading to excitotoxicity.
AMYLOID PLAQUE is NOT the Cause or even PART of the Cause. AMYLOID PLAQUE is a SYMPTOM of a wider SYSTEMIC issue.
the amyloid plaque is part of the cause of alzheimers because forms of the beta amyloid is known to be neurotoxic and are associated with the disruption of memory formation.
Brain chip – CHECK MY SITE.
PArkinsonsMichaeleilakiNagydesigN
MIdnightoilJaynagydesigNYCBC
AGraySeanFoxKaliel-grayNYCBC
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MAMEYE WILL CHECK INTO ALL OF THIS
THANKS
wouldn’t it be better to just smoke some pot and forget about all this crap? just my opinion.
In the nature magazine that I just got a few days ago there was an article stating that most doctors feel that it is the plaques which cause dementia in Alzheimers patients. Similar to CJD where prion plaques build up in the brain killing neurons in the vicinity of the plaques and causing sever dementia and eventually death.
Thanks for the video, it helped me a lot in distinguishing the difference between AD and PD
He didn’t say beta Amyloid plaque causes Parkinson’s, only that the patients have them.
Very well explained thank you for this video.
I found this video by looking up Parkinson’s Disease Dementia. I am a caregiver/health care professional and I think it’s well done.
at 7:29–AMYLOID PLAQUE is not the CAUSE of ALZHEIMERS or PARKINSONS. Instead it is a BY-PRODUCT of the DISEASE as the body seeks to PROTECT itself. In other words, it is SUPPOSED to be there! He is looking at this backwards!
Review by Bruce Trent for HOPE: Four Keys to a Better Quality of Life for Parkinson’s People
Rating:
I really appreciated the upbeat message of this book. The author shares a simple plan for dealing with the challenges of a chronic disease, without whitewashing the difficulties of daily life. He also shares a lot of personal examples, many of which I was able to identify with. My mother has Parkinson’s and I’ve done quite a bit of research, reading, etc. This book fills a gap in the literature that’s out there; most of the information is dry, “this is what’s happening now, here’s what the patient can expect in the future.” It was great to read something that really does give hope and is full of positive, realistic encouragement. I like the author’s “take the bull by the horns” attitude.
Review by Elizabeth L. Pelham for HOPE: Four Keys to a Better Quality of Life for Parkinson’s People
Rating:
This is a book that offers very PRACTICAL suggestions (because they are tried and true) ways to approach life at a time and in a circumstance when you might want to give up. It is POSITIVE without overlooking the problems and hurdles to overcome. It is PERSONAL as it depicts the adventures of a very talented and vital personality coping with a life of change and uncertainty. Whether you have Parkinson’s or not, whether you are a caregiver or not – this book will inspire you to approach life with a positive attitude and a practical application.
Review by Carolyn P Mosher for HOPE: Four Keys to a Better Quality of Life for Parkinson’s People
Rating:
This book was written for Parkinson’s People and is a must read for anyone with PD and their families. I loved the book so much I have given copies to family and friends who don’t have PD. Why? Because HOPE has something to teach us all about living with adversity (presented here in the form of chronic illness) in a way that builds on our strengths while learning to adapt to uninvited change.Especially strong are Hal’s ingsights about relationships: life partners, family, physician, and friends. I literally could not put this book down and read it in one sitting.
Review by David McIntire for HOPE: Four Keys to a Better Quality of Life for Parkinson’s People
Rating:
This is an important book for all Parkinson’s sufferers, especially those newly diagnosed who so often feel hopeless and depressed. Hal Newsom’s optimism is contagious.
Review by Paxson for HOPE: Four Keys to a Better Quality of Life for Parkinson’s People
Rating:
This book came out four or five years ago. It’s gone through one revision, and I continue to give it out to friends.
Originally I read this as a person related to someone with Parkinsons – it had helped my mother deal with the challenge. But I heard from others that it was simply inspirational for anyone dealing with a long term health challenge.
I’ve bought this book 11 times now to give to people who need some light. And I hear time and again that that’s happened – and that they get it for others.
Newsom is a real inspiration.
I am 51 Years old and parents seem to be stronger than I will Ever be.
They complain little.
They accept hard times better.
They are to be admired for their courage and strength.
I have learned so much from them.
It is nice to see the love you have for your mother in this photo and your words.
Thanks
Very beautiful and sensitive portrait-classic
Very beautiful and poignant portrait.
Getting older can be so tough, you are so right.
Moving image,rez.
I can sense both fragility and streght in her.
A fine portrait.
A lovely portrait. Surely one to print and frame.
I enjoyed this as well.
Thank-you all.
great details….
-voted as "saveme" (from the Delete me! group)
nice, sad..
-voted as "saveme2" (from the Delete me! group)
fantastic portrait! The look on her face gets the save.
-voted as "saveme3" (from the Delete me! group)
-voted as "saveme4" (from Deleteme! group)
Nice story, but tugging at the heart strings won’t get a save from me.
-voted as "deleteme2" (from the Delete me! group)
striped shirt is too distracting. Flat black background on left seems faked.
Otherwise a nice portrait.
-voted as "deleteme3" (from the Delete me! group)
Good portrait of your mom.
The composition is a bit off–cutting off the top of her head just isn’t right.
Edie
-voted as "deleteme4" (from Deleteme! group)
An impressive portrait and something that I’d be proud of if I took it.
But I wouldn’t have posted it to the deleteme group.
Why would you want anyone to delete you mum
-voted as "deleteme5" (from the Delete me! group)
Great expression, but the striped shirt makes the photo hard to look at. Like the reflection in her glasses though. HA, yo momma!
-voted as "deleteme6" (from the Delete me! group)
Sorry…
-voted as "deleteme7" (from the Delete me! group)
striped shirt: prison of disease?
A nice attempt at a portrait but your framing is off. You are showing too much her shirt and at the same time you’ve cropped top of her head off.
-voted as "deleteme9" (from the Delete me! group)
Good face and hand but the rest of the composition doesn’t cut it.
I feel for her though. My father-in-law had Parkinson’s.
It’s not easy.
-voted as "deleteme10" (from the Delete me! group)
nice and lovely. The love a mother showers to her children is the greatest!
sorry to hear about the suffering of your mom. Be strong.
saveme5
Deleted my mum!
ouch!
Excellent picture Greg.
I just feel sorry for your mum.
Keep strong!
Thanks World Traveller.
Old age is an intreresting thing – it’s similar to a terminal disease – but we ALL have to face it eventually. My goal is to provide the all the support I can for Mom to make the experience as nice as possible.
Te invito a enviar tu foto a:
Please add this photo to:
Nuestros Ancianos
Por favor incluye en los tags la frase "nuestrosancianos"
Please include in your tags the phrase: "nuestrosancianos"
Please consider adding your photo to http://www.flickr.com/groups/facesofpd/
Touching photo.
Seen in Faces of Parkinson’s
Hi, I’m an admin for a group called All about my Mother, and we’d love to have this added to the group!
beautiful portrait
well captured the feeling
Beautiful photo and words said about your mother, very nice.
Spent our 8th Mother’s Day together since this photo was taken. Lunch, ice cream, chocolate, and a little time watching TV on the couch together/napping. Priceless.