Parkinson Disease Pathophysiology Animation

04.09.10 / parkinsons disease / Author: Alex
Tags: Animation, Disease, parkinson, Pathophysiology

Parkinson disease pathophysiology – This video contains the animation of pathways and neurotransmitters of basal ganglia which cause parkinson’s disease.
Video Rating: 3 / 5

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Question by tim_ume: Why exactly causes brain cells to die in Parkinson’s disease?
I know it has got to do with age, but why exactly do the brain cells die and what is the relation between age and dying of many brain cells almost at the same time?

Best answer:

Answer by TMB
When brain cells die in the substantia nigra it doesn’t release enough dopamine. Without dopamine, signals cannot travel from SN brain cells to cells in other parts of the brain. The “instructions” that brain cells need to move muscles do not reach their targets. Eventually, walking, writing, reaching for objects, and other basic movements do not occur correctly. Muscular movement becomes weaker and more erratic.

Researchers have not yet discovered the basic cause of Parkinson’s disease. They do not know why SN brain cells lose the ability to produce dopamine. Some scientists think that the disease is hereditary. They believe that PD can be passed down from generation to generation. Other researchers think that environmental factors may be to blame. They suspect that certain chemicals in the world around us get into the human body and damage SN brain cells.

Chronic:
Recurring frequently or lasting a long time.
Dopamine:
A neurotransmitter that helps send signals that control movement.
Neurotransmitter:
A chemical that helps transmit electrical signals from one brain cell to another.
Substantia nigra:
A region of the brain that controls movement.

Add your own answer in the comments!

Aliboxingglove


Image by cobalt123
My oldest son is a gourment chef and served dinner to Muhammed Ali and his party. Aftewards he gave them a private tour of the fancy restaurant and went to a private celebrity lounge there. He and Ali shared stories about their brothers with disabilities. Ali said he could have my son’s wife come with the baby while he waited. And then Ali had a staff bring a boxing glove and signed it to my other son and drew a picture of a boxing ring on it! Wow! We later found out it is very valuable because of Ali’s Parkinson’s Disease he rarely does this anymore, let alone draw a picture.